Both estrogen androgens are found – albeit in very different concentrations and proportions – in both sexes, which cover physiological leading roles. They are so typical but not exclusive of one sex over the other. In mammals all steroid hormones, including androgens and estrogens, are synthesized from cholesterol. Looking at the various stages of steroidogenesis you can see how the secretion of androgens and estrogens both interdependent; Some of these are synthesized from androgens. Androgens may be considered pro-hormones estrogen. Aromatase steroidogenesis The various steps zymax
of steroidogenesis are regulated by a series of enzymes, whose concentration and activity constitutes the limiting step of the various biochemical steps. We have already seen how the aromatase enzyme, encoded by the CYP19 gene, is able to operate the conversion of androgens to 19 carbon atoms (androstenedione and testosterone) to estrogens to 18 carbon atoms (respectively to estrone and estradiol). Localized in the endoplasmic reticulum of the cells in which it is expressed, is an aromatase
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